Showing posts with label Metagenomics. Show all posts
Showing posts with label Metagenomics. Show all posts

Wednesday, March 10, 2021

We Have The Technology: Now That "No Lives Matter" Let The Eugenic Games Begin!

corbettreport |  On November 10, 2020, Joe Biden announced the members of a coronavirus task force that would advise his transition team on setting COVID-19-related policies for the Biden administration. That task force included Dr. Ezekiel Emanuel, a bioethicist and senior fellow at the Center for American Progress.

JOE BIDEN: So that’s why today I’ve named the COVID-19 Transition Advisory Board comprised of distinguished public health experts to help our transition team translate the Biden-Harris COVID-19 plan into action. A blueprint that we can put in place as soon as Kamala and I are sworn into office on January 20th, 2021.

SOURCE: President-elect Biden Delivers Remarks on Coronavirus Pandemic

ANCHOR: We’ve learned that a doctor from our area is on the president-elect’s task force. Eyewitness News reporter Howard Monroe picks up the story.

THOMAS FARLEY: I know he’s a very bright, capable guy and i think that’s a great choice to represent doctors in general in addressing this epidemic.

HOWARD MONROE: Philadelphia health commissioner Dr. Thomas Farley this morning on Eyewitness News. He praised president-elect Joe Biden’s transition team for picking Dr. Ezekiel Emanuel to join his coronavirus task force. He is the chair of the Department of Medical Ethics and Health Policy at the University of Pennsylvania.

SOURCE: UPenn Dr. Ezekiel Emanuel To Serve On President-Elect Biden’s Coronavirus Task Force

That announcement meant very little to the general public, who likely only know Emanuel as a talking head on tv panel discussions or as the brother of former Obama chief of staff and ex-mayor of Chicago, Rahm Emanuel. But for those who have followed Ezekiel Emanuel’s career as a bioethicist and his history of advocating controversial reforms of the American health care system, his appointment was an ominous sign of things to come.

He has argued that the Hippocratic Oath is obsolete and that it leads to doctors believing that they should do everything they can for their patients rather than letting them die to focus on higher priorities. He has argued that people should choose to die at age 75 to spare society the burden of looking after them in old age. As a health policy advisor to the Obama administration he helped craft the Affordable Care Act, which fellow Obamacare architect Jonathan Gruber admitted was only passed thanks to the stupidity of the American public.

JONATHAN GRUBER: OK? Just like the people—transparency—lack of transparency is a huge political advantage. And basically, you know, call it the stupidity of the American voter or whatever, but basically that was really critical to getting the thing to pass.

SOURCE: 3 Jonathan Gruber Videos: Americans “Too Stupid to Understand” Obamacare

During the course of the deliberations over Obamacare, the issue of “death panels” arose. Although the term “death panel” was immediately lampooned by government apologists in the media, the essence of the argument was one that Emanuel has long advocated: appointing a body or council to ration health care, effectively condemning those deemed unworthy of medical attention to death.

ROB MASS: When I first heard about you it was in the context of an article you wrote right around the time that the Affordable Care Act was under consideration. And the article was entitled “Principles for the Allocation of Scarce Medical Interventions.” I don’t know how many of you remember there was a lot of talk at the time about [how] this new Obamacare was going to create death panels. And he wrote an article which I thought should have been required reading for the entire country about how rationing medical care—you think that that’s going to start with with the Affordable Care Act? Medical care is rationed all the time and it must be rationed. Explain that.

EZEKIEL EMANUEL: So there are two kinds of “rationing,” you might say. One is absolute scarcity leading to rationing and that’s when we don’t simply don’t have enough of something and you have to choose between people. We do that with organs for transplantation. We don’t have enough. Some people will get it, other people won’t and, tragically, people will die. Similarly if we ever have a flu pandemic—not if but when we have a flu pandemic—we’re not going to have enough vaccine, we’re not going to have enough respirators, we’re not going to have enough hospital beds. We’re just going to have to choose between people.

SOURCE: Dr. Zeke Emanuel: Oncologist and Bioethicist

Wednesday, May 16, 2018

DIY DNA Tinkering...,


NYTimes  |  If nefarious biohackers were to create a biological weapon from scratch — a killer that would bounce from host to host to host, capable of reaching millions of people, unrestrained by time or distance — they would probably begin with some online shopping.

A site called Science Exchange, for example, serves as a Craigslist for DNA, a commercial ecosystem connecting almost anyone with online access and a valid credit card to companies that sell cloned DNA fragments.


Mr. Gandall, the Stanford fellow, often buys such fragments — benign ones. But the workarounds for someone with ill intent, he said, might not be hard to figure out.

Biohackers will soon be able to forgo these companies altogether with an all-in-one desktop genome printer: a device much like an inkjet printer that employs the letters AGTC — genetic base pairs — instead of the color model CMYK.

A similar device already exists for institutional labs, called BioXp 3200, which sells for about $65,000. But at-home biohackers can start with DNA Playground from Amino Labs, an Easy Bake genetic oven that costs less than an iPad, or The Odin’s Crispr gene-editing kit for $159.

Tools like these may be threatening in the wrong hands, but they also helped Mr. Gandall start a promising career.

At age 11, he picked up a virology textbook at a church book fair. Before he was old enough for a driver’s permit, he was urging his mother to shuttle him to a research job at the University of California, Irvine.

He began dressing exclusively in red polo shirts to avoid the distraction of choosing outfits. He doodled through high school — correcting biology teachers — and was kicked out of a local science fair for what was deemed reckless home-brew genetic engineering.

Mr. Gandall barely earned a high-school diploma, he said, and was rebuffed by almost every college he applied to — but later gained a bioengineering position at Stanford University.


“Pretty ironic, after they rejected me as a student,” he said.

He moved to East Palo Alto — with 14 red polo shirts — into a house with three nonbiologists, who don’t much notice that DNA is cloned in the corner of his bedroom.

His mission at Stanford is to build a body of genetic material for public use. To his fellow biohackers, it’s a noble endeavor.

To biosecurity experts, it’s tossing ammunition into trigger-happy hands.

“There are really only two things that could wipe 30 million people off of the planet: a nuclear weapon, or a biological one,” said Lawrence O. Gostin, an adviser on pandemic influenza preparedness to the World Health Organization.

“Somehow, the U.S. government fears and prepares for the former, but not remotely for the latter. It baffles me.”


Friday, December 23, 2016

The Darwinian Interlude - Metagenomics


TechnologyReview |  Carl Woese published a provocative and illuminating article, “A New Biology for a New Century,” in the June 2004 issue of Microbiology and Molecular Biology Reviews. His main theme is the obsolescence of reductionist biology as it has been practiced for the last hundred years, and the need for a new biology based on communities and ecosystems rather than on genes and molecules. He also raises another profoundly important question: when did Darwinian evolution begin? By Darwinian evolution he means evolution as Darwin himself understood it, based on the intense competition for survival among noninterbreeding species. He presents evidence that Darwinian evolution did not go back to the beginning of life. In early times, the process that he calls “horizontal gene transfer,” the sharing of genes between unrelated species, was prevalent. It becomes more prevalent the further back you go in time. Carl Woese is the world’s greatest expert in the field of microbial taxonomy. Whatever he writes, even in a speculative vein, is to be taken seriously.

Woese is postulating a golden age of pre-Darwinian life, during which horizontal gene transfer was universal and separate species did not exist. Life was then a community of cells of various kinds, sharing their genetic information so that clever chemical tricks and catalytic processes invented by one creature could be inherited by all of them. Evolution was a communal affair, the whole community advancing in metabolic and reproductive efficiency as the genes of the most efficient cells were shared. But then, one evil day, a cell resembling a primitive bacterium happened to find itself one jump ahead of its neighbors in efficiency. That cell separated itself from the community and refused to share. Its offspring became the first species. With its superior efficiency, it continued to prosper and to evolve separately. Some millions of years later, another cell separated itself from the community and became another species. And so it went on, until all life was divided into species.

Now, after some three billion years, the Darwinian era is over. The epoch of species competition came to an end about 10 thousand years ago when a single species, Homo sapiens, began to dominate and reorganize the biosphere. Since that time, cultural evolution has replaced biological evolution as the driving force of change. Cultural evolution is not Darwinian. Cultures spread by horizontal transfer of ideas more than by genetic inheritance. Cultural evolution is running a thousand times faster than Darwinian evolution, taking us into a new era of cultural interdependence that we call globalization. And now, in the last 30 years, Homo sapiens has revived the ancient pre-Darwinian practice of horizontal gene transfer, moving genes easily from microbes to plants and animals, blurring the boundaries between species. We are moving rapidly into the post-Darwinian era, when species will no longer exist, and the evolution of life will again be communal.

In the post-Darwinian era, biotechnology will be domesticated. There will be do-it-yourself kits for gardeners, who will use gene transfer to breed new varieties of roses and orchids. Also, biotech games for children, played with real eggs and seeds rather than with images on a screen. Genetic engineering, once it gets into the hands of the general public, will give us an explosion of biodiversity. Designing genomes will be a new art form, as creative as painting or sculpture. Few of the new creations will be masterpieces, but all will bring joy to their creators and diversity to our fauna and flora.

The Russian People Have Given The Kremlin Carte Blanche To Get Even

strategic culture |   Let’s start with the possible chain of events that may have led to the Crocus terror attack. This is as explosive as...